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Canada begins clinical trial of experimental COVID-19 treatment using plasma from recovered individuals.
A team of blood transfusion experts from across Canada is planning the world’s largest clinical trial of a potential treatment for COVID-19.
The study, which will involve 1,000 patients from across the country, will include at least 40 Canadian hospitals, and is being overseen by doctors from the University of Montreal, University of Ottawa, University of Toronto, McMaster and the University of British Columbia, among other schools.
The experimental treatment involves injecting antibody-rich plasma from patients who have recovered from the virus into those who are still infected. This approach has only been tried in small trials in China, Singapore, South Korea and the U.S.
It is part of a global race to find a treatment for the disease, with researchers also focusing on antivirals and medications used to treat malaria.
Donation centres across Canada will extract plasma, a straw-yellow liquid component of blood, from recovered patients and test that it has a certain minimum number of antibodies to be considered useful as an immunotherapy.
Known as convalescent plasma, the material will then be frozen, sent to participating hospitals and infused into a critical patient to see if it can help treat their illness.
In the early stages of infection, the body doesn’t produce the antibodies needed to fight off the novel coronavirus, according to Dr. Donald Arnold, a hematologist at McMaster University who is leading the trial.
“The theory is that people who have recovered from COVID infection may have antibodies to fight the virus,” Dr. Arnold said.
Canada’s two blood suppliers, Canadian Blood Services and Héma-Québec, will be managing donations from those who have fully recovered from COVID-19.
Late last month, a small Chinese study of five ventilated patients suggested the technique could be used to temper the severity of coronavirus. Three of the five patients were able to be weaned off ventilators days after receiving plasma.
During the SARS outbreak, 80 patients were treated with convalescent plasma. A review of that study showed that the earlier the transfusion, the better the outcome of the patient. None of the patients in that trial experienced adverse reactions to the treatment.
In late March, U.S. regulators allowed doctors to begin collecting recovered patients’ plasma for emergency use. Dr. Arnold, the lead of the Canadian trial, admits that the treatment is a “Hail Mary.”
While transfusion therapies aren’t typically risky for the patient, there is a chance this trial won’t have a significant impact in treating COVID-19, instead draining resources and time.
Dr. Michael Joyner of the Mayo Clinic, which will run the American national supply chain of plasma, said on Wednesday that their findings will be shared with other countries in virtual real time.
The plan for the Canadian trial came together in just days. A group of a dozen hematologists and scientists joined a Zoom call on March 29 and worked out a plan – a process that usually takes between six months and a year for a typical trial, according to Dr. Arnold.
The researchers soon learned that a parallel trial was being developed in Quebec. The following day, they merged into one large unit, with different participating institutions tackling potential subdivisions of research. Dr. Arnold said that by April 1, nearly every hospital in the country treating COVID-19 patients had signed on to participate.
Dr. Dana Devine, Canadian Blood Services’ head scientist, said that while China is now collecting donations from multiple sites, there hasn’t yet been a large patient study with a control group – meaning that certain patients don’t receive plasma – which is the gold standard for clinical trials and would be key in determining the widespread efficacy of this treatment.
She said that the group is now finalizing funding and infrastructure while Canada’s two blood banks work with provincial health ministries to contact all recovered positive COVID-19 cases about donating.
Donating plasma is no different than conventional blood donation, according to Dr. Devine, and takes about 45 minutes. She said each donor’s plasma will be studied for its virus-fighting viability.
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The coronavirus (Covid-19) cure is hidden in tea! Health workers in Chinese hospitals are treating patients with cancer by drinking tea three times a day. This is what some of the posts on social media have been claiming, in the news agency CNN and China Daily News.
The article is a reference to Chinese doctor Li Wenliang, who first warned the world about the coronavirus. As a result, many people from the common man to the tea industry are spreading this great news with great enthusiasm.
The main point of the widely circulated article is that Dr. Lee Wenliang has described the virus as a way to prevent the virus based on research on data from patients with covid-19 before his death.
He refers to a natural substance called methyl janthinid, which is a chemical compound of organic matter like caffeine, Theobromine, Thioflavin, etc. All of these ingredients are available in tea. So, drinking tea three times a day is possible to cure the coronavirus!
As scientists and researchers around the world seek ways to avoid the coronavirus, such good news is certainly a message of hope in the scary situation.
But scientific research is essential to the fact that the claim of cure is true by drinking tea. Recently, a group of researchers in Taiwan have had a promising success in finding ways to prevent the coronavirus. According to their published research article, the tea-based Thioflavin has the qualities of preventing the spread of the SARS and Mars viruses, including covid-19.
Coronavirus is basically a type of RNA dependent RNA poly merge (in short, "RDRP") that can be used to increase the number of copies of the animal body by creating numerous replicas.
Tea Thioflavin is able to prevent the spread of the coronavirus by inhibiting the effectiveness of this enzyme (Source: The Patented Chemical Structure of Anti-Sers-Cove-2 RNA Dependent RNA poly merge, Published in the Journal of Medical Virology, March 13, 2020).
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Drug war is just the beginning. How evil our human society is. Money is the main motto and everybody is rushing to get their first.
Every drug company, every country is trying to use their experimental drug to use as an alternative to corona virus cure or prevention.
But none of the drugs are FDA approved. The FDA is particularly concerned that products that claim to cure, treat or prevent serious diseases like COVID-19 may cause consumers to delay or stop appropriate medical treatment, leading to serious and life-threatening harm.
Be careful to use alternate any medicine, as it may complicate or even death. Drugs are user specific. You do not know, what is the status or prior disease patient might have? So on, so on and so on. Stop the non-sense.
Control the disease contamination and stop the spread for now. Pharmaceutical companies and researcher will come up with the solution.
Government and country's leaders’ job is to bring the normalize life to the human society and we will have plenty of time to cure and prevention for the diseases. We have to be prepared for the next wave of diseases, not yet touched to human society.
Together we all can fight back, whatever comes or trial we face on earth. Rushes and greediness will not solve the problem, rather complicate it.
Here are some info and advancement in front of us around the world:
1. Researchers around the globe are rushing to develop a vaccine to prevent the spread of COVID-19, but the development and approval process could take 18 to 24 months.
2. Gilead Sciences initiated 2 Phase 3 clinical studies to evaluate the safety and efficacy of its antiviral drug remdesivir in adults diagnosed with COVID-19.
3. Abbvie is collaborating with health authorities and institutions globally on the experimental use of its HIV medicine, lopinavir/ritonavir (Kaletra/Aluvia) to treat COVID-19.
4. The new clinical studies expand the pharma maker’s ongoing research into remdesivir, which includes two clinical trials in China’s Hubei province as well as the recently initiated clinical trial in the US led by the National Institute of Allergy and Infectious Diseases (NIAID).
5. FDA said. “Although there are investigational COVID-19 vaccines and treatments under development, these investigational products are in the early stages of product development and have not yet been fully tested for safety or effectiveness.”
6. There is already a “high level of anxiety” over the potential spread of coronaviruswhat lead to situation are companies preying on consumers by promoting products with fraudulent prevention and treatment claims. It should be stopped by all of us.
7. Last or not least Advise to all
"Plagues and pandemics are huge events affecting enormous populations; We need to battle them not impulsively but with an eye to the future course of the disease".
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Scientists in the United States, Thailand, Vietnam have already claimed to have discovered the corona virus. This time, the same claim was made by Roche Holding AG, Switzerland. They claim that the new vaccine will eliminate the corona virus.
This vaccine will heal deep wounds in the lungs of the infected patient and will balance the interleukin 6 symptom on proteins. They called the vaccine actruma. The company has already reported that the testing of the vaccine has begun in The Corona's Warehouse in Wuhan, China.
Reuters reported on Wednesday, March 04, 2020 that they sold $2 million dollars of actruma in China alone only. The company made a profit of US$2.02 million in January. The agency, which has been implementing the vaccine since February 10, said that Chinese researchers will test the vaccine on 188 corona virus-infected patients by May 10 2020.
The Chinese National Medical Product Administration is trying to test roche-made vaccine. The organization says that the actruma works well in the patient's interleukin 6 symptom. It also heals the wound of the lungs and strengthens the respiratory tract. The patient who is infected is free of the corona.
Meanwhile, there has been no specific message from china health agencies on the actruma. The Chinese administration has not officially sealed roche's drug. They said the matter is under observation. However, many Chinese virologists are advising to apply the actruma to patients with Covid-19 (corona virus).
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Find out how to test yourself corona virus in just 10 seconds to see if you're infected with the corona!
Check yourself with the Corona virus (Covid-19): How you know that you condition is very serious. If 50% of the lungs are fibrosis (increased in the subtle parts) with the corona virus, It means your condition is very serious.
Go to hospital directly with high protection, that no one get virus from you. Hospital should isolate you. Mild symptom can make you self-isolation in your own house with different room and protection.
one person only will shall take care one sick patient. Follow this guide line when you are in self-isolation in your own house.
Experts in Taiwan have discovered a method of self-testing whether someone has been infected with corona, which any one can do every morning and be safe by checking it once in a few seconds.
The test is: get up every morning and take a long, deep breath to hold it for a little longer than ten seconds in a clean environment. If you don't have any cough, chest pain or stress, no discomfort, that means no fibrosis in your lungs, no infection, you are completely risk-free.
Japanese doctors have given another very good advice that everyone should try to avoid drying your throat and mouth, wet. So drink water every 15 minutes, even if it is a little bit of a steam.
Because somehow the virus enters your mouth and it will go to the stomach with water, and the stomach acid will kill the virus in a moment. Be good, stay well. May Allah protect us all from all the calamities.
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The beneficial properties of black seed oil include anti-inflammatory, antibacterial, antioxidant, anticancer, antifungal, antihistamine, antiasthmatic, anticoagulant, and antiviral. When you use black seed oil for treating most health ailments, you just need to consume one teaspoon of black seed oil per day.
Autoimmunity is the direct result of fungi attacking the body, over time if your body doesn’t rid these toxins you develop “auto immunity” Black seed is one of the best things for fungi/parasites. Imagine that. Mold made me extremely sick and doctors couldn’t figure out what it was, got told I had bad anxiety. Gave black seed a try and starting to feel better.
Cleopatra used it as a beauty treatment. Queen Nefertiti used black seed oil to bring luster to her hair and nails.
Black seeds contain over 100 chemical compounds and some of the ingredients are yet to be discovered and identified. The main active ingredient in black seed oil is crystalline nigellone.
The seed oil also contains beta sitosterol, thymoquinone, myristic acid, palmitic acid, stearic acid, palmitoleic acid, oleic acid, linoleic acid, arachidonic acid, proteins and vitamins B1, B2 and B3. The seed oil also contains calcium, folic acid, iron, copper, zinc and phosphorous.
The high content of phytosterols found in Black Cumin Oil – are also necessary for the human body for natural production of hormones, provitamin D and bile acid – aiding in a prevention of endocrine disorders, immune deficiency and the #1 killer – cardiovascular disease. Dr. Gary Null stated – “every time you take black cumin you are stimulating your immune system to fight on your behalf and increase natural killer cells.” Thus, referring to its ability to improve the immune system, and help treat even the most impossible invaders like cancer and HIV, successfully.
In turn, Black Cumin supports the entire body. Its immune-building properties and active compounds have been proven to help fight a never-ending list of diseases and autoimmune disorders – via the boosting of the body’s immune cell production, bone marrow, and natural interferon. Even for people in the best state of health, consuming Black Cumin regularly – have greatly increased their vitality and well-being!
Note:People with medication should consult with their family doctor before using any natural oil and natural products in their diet.
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1.Cure migraines with coffee
Prone to migraines? Try muscling-up your painkiller with a coffee chaser. Whatever over-the-counter pain med you prefer, researchers at the National Headache Foundation say washing it down with a strong 12- ounce cup of coffee will boost the effectiveness of your medication by 40 percent or more. Experts say caffeine stimulates the stomach lining to absorb painkillers more quickly and more effectively.
2. Tame leg cramps with tomato juice
At least one in five people regularly struggle with leg cramps. The culprit? Potassium deficiencies, which occur when this mineral is flushed out by diuretics, caffeinated beverages or heavy perspiration during exercise. But sip 10 ounces of potassium-rich tomato juice daily and you'll not only speed your recovery, you'll reduce your risk of painful cramp flare-ups in as little as 10 days, say UCLA researchers.
3. Prevent PMS with yogurt
Up to 80 percent of women will struggle with premenstrual syndrome and its uncomfortable symptoms, report Yale researchers. The reason: Their nervous systems are sensitive to the ups and downs in estrogen and progesterone that occur naturally every month. But snacking on 2 cups of yogurt a day can slash these symptoms by 48 percent, say researchers at New York ?s Columbia University . ?Yogurt is rich in calcium, a mineral that naturally calms the nervous system, preventing painful symptoms even when hormones are in flux,? explains Mary Jane Minkin, M.D., a professor of gynecology at Yale University .
4. Cure a toothache with cloves
Got a toothache and can?t get to the dentist? Gently chewing on a clove can ease tooth pain and gum inflammation for two hours straight, say UCLA researchers. Experts point to a natural compound in cloves called eugenol, a powerful, natural anesthetic. Bonus: Sprinkling a ¼ teaspoon of ground cloves on meals daily may also protect your ticker. Scientists say this simple action helps stabilize blood sugar, plus dampen production of artery-clogging cholesterol in as little as three weeks.
Note:People with medication should consult with their family doctor before using any natural oil and natural products in their diet.
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So you can use domestic materials to bring bright glowing white to the skin. To bring or maintain the brightness of the skin the household natural product can be used and getting popularity in the beauty world. There are various types of domestic facepack to make skin glowing.
Find out 3 ways to get to know the most simple processes. Skin is becoming more glowing and white quickly in behavior. Find out in next slides what the procedures are.
1. Tamarind pulp to the skin for 15 minutes. You have to wash your face with water when dry. Use of two days in a week will have good results.
2. Get the dense mixture of lemon and honey mixing together. Mixture the face clean and wait a while. After minutes 15, wash your face with cold water. There will be good results in the use of 3 or 4 days a week.
3. Pink lentil(Musur dal) to soak for a while in the water. Put a thick paste in the wet Pink lentil paste into the mouth. Wait until the drying. Then wash your face with water.
Note:People with medication should consult with their family doctor before using any natural oil and natural products in their diet.
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Benefits of horseradish Blueberries Honey and Flax
1. Heal sinus problems with horseradish
Latest studies show sinusitis is the nation's number one chronic health problem. And this condition doesn't just spur congestion and facial pain, it also makes sufferers six times more likely to feel achy all-over.
Horseradish to the rescue! According to German researchers, this eye-watering condiment naturally revs up blood flow to the sinus cavities, helping to open and drain clogged sinuses and heal sinus infections more quickly than decongestant sprays do.
The study-recommended dose: One teaspoon twice daily (either on its own or used as a sandwich or meat topping) until symptoms clear.
2. Beat bladder infections with blueberries
Eating 1 cup of blueberries daily, whether you opt for the fresh, frozen or in juice form, can cut your risk of a urinary tract infection (UTIs) by 60 percent, according to researchers at New Jersey's Rutgers University.
That's because blueberries are loaded with tannins, plant compounds that wrap around problem-causing bacteria in the bladder, so they can?t get a toehold and create an infection, explains Amy Howell, Ph.D. a scientist at Rutgers University.
3. Heal mouth sores with honey
Dab painful canker and cold sores with unpasteurized honey four times daily until these skin woes disappear, and they'll heal 43 percent faster than if you use a prescription cream, say researchers at the Dubai Specialized Medical Center in the United Arab Emirates.
Raw honey?s natural enzymes zap inflammation, destroy invading viruses and speed the healing of damaged tissues, say the study authors.
4. Fight breast pain with flax
In one recent study, adding 3 tablespoons of ground flax to their daily diet eased breast soreness for one in three women within 12 weeks.
Scientists credit flax?s phytoestrogens, natural plant compounds that prevent the estrogen spikes that can trigger breast pain. More good news: You don't have to be a master baker to sneak this healthy seed into your diet.
Just sprinkle ground flax on oatmeal, yogurt, applesauce or add it to smoothies and veggie dips.
Note:People with medication should consult with their family doctor before using any natural oil and natural products in their diet.
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Natural painkiller and it's benefit
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Natural Pain killer and it's benefits
Prevent digestive upsets with pineapple
Got gas? One cup of fresh pineapple daily can cut painful bloating within 72 hours, say researchers at California's Stanford University.
That's because pineapple is natually packed with proteolytic enzymes, digestive aids that help speed the breakdown of pain-causing proteins in the stomach and small intestine, say USDA researchers.
Relax painful muscles with peppermint
Suffering from tight, sore muscles? Stubborn knots can hang around for months if they aren?t properly treated, says naturopath Mark Stengler, N.D., author of the book, The Natural Physician?s Healing Therapies.
His advice: Three times each week, soak in a warm tub scented with 10 drops of peppermint oil. The warm water will relax your muscles, while the peppermint oil will naturally soothe your nerves -- a combo that can ease muscle cramping 25 percent more effectively than over-the-counter painkillers, and cut the frequency of future flare-ups in half, says Stengler.
Give your back some TLC with grapes
Got an achy back? Grapes could be the ticket to a speedy recovery. Recent studies at Ohio State University suggest eating a heaping cup of grapes daily can relax tight blood vessels, significantly improving blood flow to damaged back tissues (and often within three hours of enjoying the first bowl).
That's great news because your back?s vertebrae and shock-absorbing discs are completely dependent on nearby blood vessels to bring them healing nutrients and oxygen, so improving blood flow is essential for healing damaged back tissue, says Stengler.
Wash away pain injuries with water
Whether it's your feet, your knees or your shoulders that are throbbing, experts at New York ?s Manhattan College , say you could kick-start your recovery in one week just by drinking eight 8-ounce glasses of water daily.
Why Experts say water dilutes, and then helps flush out, histamine, a pain-triggering compound produced by injured tissues.
Plus water is a key building block of the cartilage that cushions the ends of your bones, your joints? lubricating fluid, and the soft discs in your spine,adds Susan M. Kleiner, Ph.D., author of the book, The Good Mood Diet. And when these tissues are well-hydrated, they can move and glide over each other without causing pain.? One caveat: Be sure to measure your drinking glasses to find out how large they really are before you start sipping, she says. Today's juice glasses often hold more than 12 ounces, which means five servings could be enough to meet your daily goal.
Note:People with medication should consult with their family doctor before using any natural oil and natural products in their diet.
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1) Do not be rude to him due to any mistake of the child, Then your child will grow up liar.
2) Do not shorten your baby in front of everyone, Then your child will lose confidence.
3) Do not impose a decision on the child's decision, Then he will never have the ability to decide on his own.
4) Do not take responsibility for your child when you have problems in any matter, let him cope. Otherwise, he would be very fearful.
5) Do not compare the other with the child, Then he will learn to jealous and envy people.
6) Do not bother your child, Then he will feel guilty for everything later.
7) Do not break your promise to your child, Otherwise, he will not understand the value of the promise later.
8) Do not despise their interest, Then she will be frustrated with herself.
9) Teach your child how to control emotions, Otherwise it will suffer from nervous problems.
10)Find, if they suspect their abilities, they will remember it for life.
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The possible health benefits of consuming papaya include a reduced risk of heart disease, diabetes, cancer, aiding in digestion, improving blood glucose control in people with diabetes, lowering blood pressure, and improving wound healing.
Papaya contains several unique protein-digesting enzymes including papain and chymopapain. These enzymes have been shown to help lower inflammation and to improve healing from burns. In addition, the antioxidant nutrients found in papaya, including vitamin C and beta-carotene, are also very good at reducing inflammation.
Papaya seeds contain nutrients that help heal cirrhosis of the liver and improve kidney health, preventing renal failure. Its anti-inflammatory properties help treat arthritis and joint disease. It contains an alkaloid called carpaine that kills intestinal worms and amoeba parasites.
Precautions and Warnings
Despite all of their beneficial properties, papaya seeds do have some side effects to be aware of and certain people shouldn’t take them. Please check if any of these apply to you before eating papaya seeds.
As a precaution, pregnant women should not use papaya seeds or the enzyme rich green papaya powder. This warning on their use would also extend to mothers who are breastfeeding.
Additionally, while papaya seeds do have strong anti-parasitic properties, they may be too powerful for young children’s gastrointestinal tracts, so a doctor should be consulted before giving them to infants.
There is also some animal research suggesting that eating papaya seeds may temporarily but greatly reduce a man’s fertility to the point that would make pregnancy unlikely.
Patients using blood thinning medications like warfarin or aspirin should consult their doctor before they eat papaya seeds regularly as papain may increase the actions of these drugs.
Note:People with medication should consult with their family doctor before using any natural oil and natural products in their diet.